The League of Super Evil or L.O.S.E. is a team of villains, and the main focus of the TV show of the same name. The group is fairly unknown in the supervillain circles of Metrotown, but it's leader has big plans for infamy. They live in a suburban neighborhood in their Lair.
- Voltar - the leader of the group, he has a very clear idea of what evil is, and will not stray from it. He is the main motivator and schemer of the team.
- Doktor Frogg - a mad scientist and the brains of the group, he is also the most accident-prone.
- Red Menace - a big, gentle guy who really isn't that evil, he is the brawns of the group.
- Doomageddon - the team pet, it is a destructive and disobedient creature from another dimension.
- Henchbots 017 and 032 - a pair of fragile robots that work for the group.